Side Effect was founded in 2004. The very first appearance was " The Fountain Of Youth" show,at BME 2 Club, which was the farewell party of the final year students from U.F.L.Since then, they've been playing frequently. They organized some gigs under the name of " Underground Soap Opera" and rocked with many underground bands in 2005, 2006 and 2007. Playing with the local famous band, Big Bag, they've been noticed even more than what they did in the past few years.

They performed in Kurt Cobain Memorial shows two years in a row, 15 Years Later on April 8 2009 and 16 Years Later on April 8 2010.On 17th of August, 2010, they played with Handsome Furs from Montreal, Canada. So many foreigners came to that show and they achieved great exposure. William ,who is the freelance music writer for Rolling Stone magazine, says " Side Effect is the first indie rock band in Myanmar".But they said,"We do not focus on genre but artworks. Three of us have individual abilities and creativity. Different influences. So, we create songs freely then check them out. And, it's like, 'What the fuck! It sounds great.Let's go that way.' "